Congenital Non-Epidermolytic Ichthyosis in Two Littermate Mixed-Breed Yorkshire Terriers

Congenital non-epidermolytic ichthyosis was diagnosed in two littermate mixed-breed Yorkshire terrier puppies. Histopathological results confirmed lamellar orthokeratosis; genetic testing for known mutations was negative. Topical treatment improved clinical signs, yet relapse occurred upon discontinuation. This case expands the breeds affected and emphasises the need for life-long management.

Authors: C. Lorente-Méndez, S. Peña and A. Cerezo Title: Congenital Non-Epidermolytic Ichthyosis in Two Littermate Mixed-Breed Yorkshire Terriers Full source: Vet Dermatol, 2026,Vol 37, Iss 2, pp 222-226
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Abstract	Source
Congenital non-epidermolytic ichthyosis was diagnosed in two littermate mixed-breed Yorkshire terrier puppies. Histopathological results confirmed lamellar orthokeratosis; genetic testing for known mutations was negative. Topical treatment improved clinical signs, yet relapse occurred upon discontinuation. This case expands the breeds affected and emphasises the need for life-long management.