Successful deslorelin implant treatment in a neutered female Pomeranian dog with Alopecia X

The Pomeranian dog is recognized as one of the predisposed breeds for alopecia X, a noninflammatory hair cycle arrest disorder. Although it is considered a cosmetic issue unrelated to systemic illness, having a pet with alopecia can be distressing for owners. Sex steroid imbalance seems to influence the development of alopecia X, but the exact pathogenesis is still unknown. Although some treatment alternatives are currently available for alopecia X, results can vary, as well as costs, risks, and owner adherence. GnRH analogs have been used extensively in the modulation of sex hormone synthesis in humans. Previous studies support the use of the GnRH analog in treating male dogs with alopecia X, but current literature discourages its use in females. We aim to report the first scientific description of a neutered female dog with alopecia X successfully treated with a 4.7 mg deslorelin acetate implant after failing to respond to melatonin. Profuse hair regrowth took 9 months to occur after the first implant, but the treatment was considered uncomplicated, cost-effective, and safe.

Authors: P. A. B. Coimbra and A. B. Vieira Title: Successful deslorelin implant treatment in a neutered female Pomeranian dog with Alopecia X Full source: Journal, Year,Vol Volume, Iss Issue, pp Pages
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Abstract	Source
The Pomeranian dog is recognized as one of the predisposed breeds for alopecia X, a noninflammatory hair cycle arrest disorder. Although it is considered a cosmetic issue unrelated to systemic illness, having a pet with alopecia can be distressing for owners. Sex steroid imbalance seems to influence the development of alopecia X, but the exact pathogenesis is still unknown. Although some treatment alternatives are currently available for alopecia X, results can vary, as well as costs, risks, and owner adherence. GnRH analogs have been used extensively in the modulation of sex hormone synthesis in humans. Previous studies support the use of the GnRH analog in treating male dogs with alopecia X, but current literature discourages its use in females. We aim to report the first scientific description of a neutered female dog with alopecia X successfully treated with a 4.7 mg deslorelin acetate implant after failing to respond to melatonin. Profuse hair regrowth took 9 months to occur after the first implant, but the treatment was considered uncomplicated, cost-effective, and safe.