Peripheral Eosinophilia in a Confirmed Case of Canine Acute Eosinophilic Dermatitis with Edema (Wells-Like Syndrome)

This case report describes a peripheral eosinophilia in a dog diagnosed with canine acute eosinophilic dermatitis with edema (CAEDE). A 1-year-old female spayed Terrier Mix canine presented as a referral from their primary care veterinarian for gastrointestinal signs that were recently treated, but ongoing, and a new dermatopathy. Her leukogram revealed an eosinophilia, not previously present at the onset of her gastrointestinal signs, and skin biopsies were consistent with diagnosis of CAEDE. Although the definitive cause of the development of CAEDE in this patient is ultimately unknown, the patient made a full recovery following treatment with corticosteroids over a three-week treatment course. To the authors' knowledge, this is the first report of a confirmed diagnosis of CAEDE to present with peripheral eosinophilia on complete blood count (IDEXX Procyte Dx).

Authors: A. Pace and J. Hendricks Title: Peripheral Eosinophilia in a Confirmed Case of Canine Acute Eosinophilic Dermatitis with Edema (Wells-Like Syndrome) Full source: Vet Med (Auckl), 2025,Vol 16, pp 9-16
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Abstract	Source
This case report describes a peripheral eosinophilia in a dog diagnosed with canine acute eosinophilic dermatitis with edema (CAEDE). A 1-year-old female spayed Terrier Mix canine presented as a referral from their primary care veterinarian for gastrointestinal signs that were recently treated, but ongoing, and a new dermatopathy. Her leukogram revealed an eosinophilia, not previously present at the onset of her gastrointestinal signs, and skin biopsies were consistent with diagnosis of CAEDE. Although the definitive cause of the development of CAEDE in this patient is ultimately unknown, the patient made a full recovery following treatment with corticosteroids over a three-week treatment course. To the authors' knowledge, this is the first report of a confirmed diagnosis of CAEDE to present with peripheral eosinophilia on complete blood count (IDEXX Procyte Dx).